Monday
Medium (NBC, 10pm) – This hit show returns for its second season. Inspired by real-life psychic detective Allison Dubois, Medium stars Patricia Arquette as a psychic who helps police solve difficult cases.
Tuesday
Supernatural (WB, 9pm) – Two young brothers traverse the country in their '69 Chevy Impala in their mission to carry on their missing father's quest to seek out and silence the supernatural forces responsible for their mother's murder 20 years ago.
Wednesday
Ghost Hunters (SciFi, 8pm) – The Rhode Island-based TAPS ghost investigation team returns for a second season, taking their high-tech equipment and open-minded skepticism to various haunted locations around the US.
One Step Beyond (Discovery, 8 pm) – Examines various aspects of the paranormal, including ghosts, psychic phenomena, cryptids and more.
Lost (ABC, 9pm) – Something weird is going on on the island where survivors of a plane crash have been marooned. We’re not sure if there’s something paranormal there or not, but there may be a monster of some kind… as well as other mysteries. Second season.
Invasion (ABC, 10pm) – Are extraterrestrials already among us, undetected? That’s the premise of this new show that suggests that all the devastating natural disasters we are experiencing may be a smokescreen for an alien plot.
Thursday
Nightstalker (ABC, 9pm) – This remake of the 1970s series starring Darren McGavin focuses on the investigations of Carl Kolchak who, like Mulder and Scully, has a nose for supernatural mysteries.
Friday
Ghost Whisperer (CBS, 8pm) - Jennifer Love Hewitt stars as a newly married young woman who can communicate with spirits of the dead, a gift that intrudes on her desire to lead a normal life. Inspired by the work of psychic James Van Praagh. New show.
Threshold (CBS, 9pm) – A cargo freighter encounters something unexpected out at sea: an extraterrestrial spaceship. Operation: Threshold is put into force to find out the intentions of the aliens, good or bad. New show.
Most Haunted (Travel Channel, 9pm) – This British import chronicles the investigations of some of the most haunted locations around Europe. The ghost-hunting team includes medium Derek Acorah and some top experts from the paranormal field.
Other
Masters of Horror (Showtime, date and times not announced) – This new anthology series features such well-known directors as John Carpenter, Joe Dante, Tobe Hooper and George Romero offering horror-themed films.
Ghost Encounters (to be announced) – Ghost researcher Peter James and co-host Fiona Horne unveil the mysteries of the spirit realm in haunted locations around the world, along with various celebrity guests.